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Anemia stems from letter a lowered quantity of purple blood cells and also the ensuing deficiency fashionable oxygen and consistency tissues.
The disease is caused by A mutated version of the gene that helps make haemoglobin — a protein that carries atomic number 8 in red ancestry cells.
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Where is sickle cell anemia most common in the world?
Sickle cell disease (SCD) is the most common symptomatic hemoglobinopathy in the world, largely seen in parts of Africa, the Middle East, India and in some regions of Mediterranean countries. 2. SCA is a monogenic disorder with an autosomal recessive inheritance.
How old is child with sickle cell anemia in India?
A three years old male child, native of Jharkhand, Central India presented with mild pallor, icterus, and history of on and off abdominal and joint pains. On examination the child had mild splenomegaly. He had history of two prior hospital admissions.
When do symptoms of sickle cell anemia appear?
Neonates are asymptomatic due to high HbF, but symptoms begin to appear by six months of age. Many infants present with lethal complications at first presentation. This emphasizes the importance of newborn screening in these susceptible pre-symptomatic cases in endemic regions.
Is there a cure for sickle cell anemia?
Treatment of sickle cell disease generally aims at relieving symptoms and preventing infections, sickle cell crises and long-term complications. Stem cell transplant is the only potential cure available presently. Peripheral smear showing sickle cells, elliptocytes and ovalocytes.
Last Update: Oct 2021
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